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Similarly, a significant decrease in mean sperm concentration from 113 10 6 to 66 10 6 /ml was observed between 1940 and 1990 with an estimated decrease of 0.934 10 6 /ml per year (Carlsen et al

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Risk ratios, relative risk, and continuous outcomes are commonly used in meta-analyses and sensitivity analyses to assess the effectiveness and safety of vaping for smoking cessation, but some systematic reviews note insufficient evidence for long-term outcomes, emphasising the need for ongoing data collection, data extraction, and sensitivity analysis in future research